Epilepsy and Cognition
Research Project
Laboratory of Emotions Neurobiology currently coordinates research program on cognitive dysfunctions in temporal lobe epilepsy.
Cumulating experimental data indicates the correlation between temporal lobe epilepsy and neuropsychiatric disorders which might suggests their common etiology. A crucial role in this correlation is played by hippocampus, a brain structure responsible for cognition and seizure origin in temporal lobe. Various biological mechanisms may contribute to the common etiology of temporal lobe epilepsy and neuropsychiatric disorders, nevertheless, scientific investigations are mostly concentrated on synaptic dysfunctions. Our experimental data indicates that synaptopathy related to a very specialized group of hippocampal neurons is implicated in the development of temporal lobe epilepsy and comorbid neuropsychiatric disfunctions.
​
Aim of the project is to investigate the physiological consequence of giant mossy fiber boutons dispersion -an underrecognized phenomenon that is associated with spectrum of epileptiform neuropsychiatric conditions.
​
Realization of this project will increase our knowledge about function of neuronal connections and will also help us to understand how synaptopathies lead to the brain malfunction. The undertaken study fits into frames of most challenging research issues looking for biological mechanism underling neurological impairments.
​
​
Click below to discover more
Contact
Laboratory is located in the Ochota campus (Warsaw, Poland) which enjoys a vibrant and collegial scientific environment. The city is safe, green, and offers great culture, healthy lifestyle, solid economy, and a lot to do.
Adam Gorlewicz
Laboratory of Emotions Neurobiology
Nencki Institute of Experimental Biology
Pasteur Street 02-093 Warsaw